Hypertension as predictor of sunitinib treatment outcome in metastatic renal cell carcinoma
Authors: Bono, Petri; Rautiola, Juhana; Utriainen, Tapio; Joensuu, Heikki
Source: Acta Oncologica, Volume 50, Number 4, May 2011 , pp. 569-573(5)
Publisher: Informa Healthcare
Abstract:<title>Abstract</title> Hypertension and hypothyreoidism are frequent side effects of VEGFR-inhibitors. We investigated whether hypertension or hypothyreoidism diagnosed during sunitinib treatment is associated with treatment efficacy. Material and methods. Sixty-four consecutive patients with metastatic renal cell cancer (RCC) were treated with sunitinib in a single center. Hypertension was defined as persistent blood pressure >150/100 mmHg or blood pressure requiring intensification of pre-existing anti-hypertensive medication. Hypothyreoidism was defined as elevation of TSH levels and clinical symptoms requiring hormone replacement therapy (≥≥Gr. II hypothyreoidim). Results. Twenty-four (38%) patients developed hypertension and 12 (19%) hypothyreoidism. The dose of sunitinib administered was not significantly associated with hypertension or hypothyreoidism. There was no correlation between hypertension and hypothyreoidism. Hypertension was associated with frequent tumor response to sunitinib, a long time to disease progression and long overall survival (p== 0.001, 0.0003 and 0.001, respectively). In a multivariate analysis, hypertension was an independent predictor of progression-free survival (hazard ratio, 0.21; 95% CI 0.076 to 0.59, p==0.0030). There were no statistically significant differences in the frequency of ≥≥ grade 3 adverse events between patients with or without hypertension. Conclusion. Sunitinib-associated hypertension may be a strong predictive marker for treatment efficacy in metastatic RCC.
Document Type: Research article
Publication date: 2011-05-01