Prognostic Significance of Intratumour Microvessel Density and Haemoglobin Level in Carcinoma of the Uterine Cervix
Authors: Gasinska A.; Urbanski K.; Adamczyk A.; Pudelek J.; Lind B.K.; Brahme A.
Source: Acta Oncologica, Volume 41, Number 5, 1 September 2002 , pp. 437-443(7)
Publisher: Informa Healthcare
Abstract:The prognostic significance of intratumour microvessel density (IMD) and haemoglobin (Hb) level was studied in 152 (FIGO stage IB -IIIB) cervical cancer patients before radiotherapy. Patients' age and tumour stage, grade and degree of keratinization were also studied. IMD measurement expressed as the mean vessel count per 1 mm2 was performed on formalin-fixed, paraffin-embedded tumour biopsies stained with anti-factor VIII antibody (DAKO Ltd.) using immunohistochemistry and the vascular hot-spot technique. The median age of patients was 55 years (29-80). Median values for IMD and Hb level were: 142.5 (range 56.3-476.6) vessels/mm2 and 129 (range 81-160) g/l, respectively. The median time of follow-up was 26 months, with a range of 2-145 months. Tumour stage (p=0.7009), grade (p=0.6660) and degree of keratinization (0.2669) were not significant in the Kaplan-Meier univariate analysis. However, patients' age >50 years (p=0.0079), high vascularity (IMD >190.0 vessels/mm2, minimal cut-off point, p=0.0503) and Hb concentration >116 g/l (p=0.0213) were favourable prognostic factors for cervical cancer treated with radiotherapy. In the Cox multivariate analysis only higher vascularity (IMD>190/mm2 and Hb concentration >116 g/l were favourable prognostic factors in terms of patients' survival. However, when a Cox analysis was done separately for keratinizing and non-keratinizing tumours, it was found that higher vascularity was significant only for keratinizing, and higher Hb level only for non-keratinizing cancers.
Document Type: Research article
Publication date: 2002-09-01