History, Present Status and Future of Sentinel Node Biopsy in Breast Cancer: The Mary Béves Lecture
Authors: Mansel R. E.; Khonji N. I.; Clarke D.
Source: Acta Oncologica, Volume 39, Number 3, 11 October 2000 , pp. 265-268(4)
Publisher: Informa Healthcare
Abstract:The word 'Sentinel' is defined in The Oxford English Dictionary as 'a guard, one who keeps watch or a sentry'. When translated to the concept of a tumour and its lymph node drainage, the sentinel node could be interpreted to mean the lymph node that guards or keeps watch over a tumour. The sentinel lymph node can thus be defined as the first lymph node that drains a primary tumour within the regional lymphatic basin of that tumour. We know that tumour progression in breast cancer often occurs in an orderly, progressive fashion 12. So in theory, if the sentinel node is tumour free then the rest of the nodes in the lymphatic basin should also be uninvolved by the tumour.
Document Type: Research article
Publication date: 2000-10-11