High-grade Non-Hodgkin's Lymphoma Treated in Northern Norway: Treatment, Outcome, and Prognostic Factors
Authors: Bremnes, Roy Martin; Bremnes, Yngve; Dønnem, Tom
Source: Acta Oncologica, Volume 38, Number 1, 15 February 1999 , pp. 117-124(8)
Publisher: Informa Healthcare
Abstract:In an unselected group of patients with high-grade non-Hodgkin's lymphoma (HG-NHL) treated at our institution during a 10-year period (1986-1995), we studied treatment outcome and influence of possible prognostic factors. 187 HG-NHL patients were analysed retrospectively with regard to personal, treatment and disease-specific characteristics. Median age was 65 years and the male : female ratio was 1.2 : 1. Over a median follow-up of 57 months the overall response rate was 87% (complete response 72%, partial response 15%). The 2- and 5-year cumulative disease-specific survival rates were 64±4% (mean±SEM) and 48±5%, respectively. In a univariate analysis, the following variables were associated with prognosis in terms of survival: Patient age, clinical stage, performance status, bone-marrow infiltration, haemoglobin, erythrocyte sedimentation rate, lactate dehydrogenase (LDH), and serum albumin. In multivariate analyses, patient age, performance status, LDH, and haemoglobin came out as independent prognostic factors for survival.
Document Type: Research Article
Publication date: 1999-02-15