Primary Nocardia meningitis in a patient without a predisposingcondition: Case report and review of the literature

Authors: Soub, Hussam Al¹; Almaslamani, Mona¹; Khuwaiter, Jameela Al¹; Deeb, Yasser El¹; Khatab, Mohammed Abu¹

Source: Scandinavian Journal of Infectious Diseases, Volume 39, Number 8, 2007 , pp. 737-741(5)

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By this author: Soub, Hussam Al ; Almaslamani, Mona ; Khuwaiter, Jameela Al ; Deeb, Yasser El ; Khatab, Mohammed Abu

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Abstract:

A case of primary Nocardia meningitis in a patient without a predisposing condition is presented and 4 other reported cases are reviewed. The presenting features were fever, headache, altered consciousness, and neck stiffness. Cerebrospinal fluid examination (CSF) revealed hypoglycorrhachia (<40 mg/dl), elevated protein (>100 mg/dl), and pleocytosis with predominant neutrophils in all patients. Culture of CSF was positive for Nocardia in 4 of the 5 patients. Mortality was 50%. Diagnosis was frequently delayed and this probably contributed to the high mortality. Compared with Nocardia meningitis in association with a predisposing condition, primary Nocardia meningitis without a predisposing condition has similar clinical features and outcome.

Document Type: Research article

DOI: 10.1080/00365540701199873

Affiliations: 1: From the Department of Internal Medicine, Hamad Medical Corporation, Doha-Qatar