Authors: Ravn, Pernille¹; Munk, Martin E.²; Bengaard Andersen, Åse³; Lundgren, Bettina⁴; Nielsen, Lars N.¹; Lillebaek, Troels⁵; Soerensen, Inge J.⁶; Andersen, Peter⁷; Weldingh, Karin⁷

Source: Scandinavian Journal of Infectious Diseases, Volume 36, Numbers 6-7, Numbers 6-7/July 2004 , pp. 499-501(3)

Publisher: Informa Healthcare

Abstract:

A patient with polymyositis developed tuberculosis during immunosuppressive treatment. Tuberculin Skin Test and chest X-ray failed to demonstrate latent tuberculosis, whereas a blood sample that was tested with a modified QuantiFERON®-TB-assay, using the recombinant ESAT-6 and CFP-10, was positive indicating that this patient was latently infected before immunosuppressive therapy. This case indicates the risk of progressing from latent to active tuberculosis given that the subject is RD1 responsive, and we believe that preventive anti-tuberculous treatment could have prevented this case of tuberculosis. We suggest that RD1 based tests are evaluated further in immunocompromised patients.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365540410015222

Affiliations: 1: Department of Infectious Diseases Hvidovre Hospital Copenhagen 2: Genmab A/S Copenhagen 3: Department of Infectious Diseases Rigshospitalet Copenhagen 4: Department for Microbiology Hvidovre Hospital Hvidovre 5: International Reference Laboratory of Mycobacteriology Statens Serum Institute Copenhagen 6: Department of Reumatology Rigshospitalet Copenhagen 7: Department of Infectious Disease Immunology Staten Serum Institute Copenhagen S

Publication date: 2004-07-01

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