Dietary supplementation of carbonate promotes spontaneous tumorigenesis in a rat gastric stump model

Authors: Ehrnström, Roy A¹; Veress, Béla¹; Arvidsson, Stefan²; Sternby, Nils H¹; Andersson, Tommy³; Lindström, Clas G¹

Source: Scandinavian Journal of Gastroenterology, Volume 41, Number 1, Number 1/January 2006 , pp. 12-20(9)

Publisher: Informa Healthcare

Buy & download fulltext article:

Price: $34.29 plus tax (Refund Policy)

Abstract:

Objective . Food supplements are known to affect the development of gastric adenocarcinoma. In this study, an animal model of gastric resection was used to investigate the effects of calcium carbonate on spontaneous development of gastric adenocarcinoma. Material and methods . Ninety-two Wistar rats with gastric resections (performed to induce spontaneous gastric cancer) and 60 without resections (controls) were used to analyse the carcinogenic potential of different ion supplements in food. Results . Among the resected rats, cancer developed in 3 out of 18 (17%, NS) given NaCl but in 11 out of 18 (61%, p 4 , which was lower than the rate observed in the resected control group fed a normal diet, although this difference was not statistically significant. However, tumour development increased significantly in the resected animals given a diet supplemented with NaHCO 3 (tumours in 13 out of 24 rats, 54%; p

Keywords: Cancer; calcium; carbonate; experimental; gastric; rat

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365520510024106

Affiliations: 1: Divisions of Pathology, Lund University, Malmö University Hospital, Malmö 2: Slottstaden Medical Clinic, Malmö, Sweden 3: Experimental Pathology, Department of Laboratory Medicine, Lund University, Malmö University Hospital, Malmö

Publication date: 2006-01-01

More about this publication?