Authors: Ladefoged, Karin¹; Kristian Munck, Lars¹; Jorgensen, Frank¹; Engel, Peter²

Source: Scandinavian Journal of Gastroenterology, Volume 40, Number 10, October 2005 , pp. 1192-1196(5)

Publisher: Informa Healthcare

Abstract:

Objective. The purpose of the study was to evaluate the incidence of discontinuous inflammation of the appendiceal orifice in patients undergoing colonoscopy for diagnosis or surveillance of colonic disease. Material and methods. Consecutive and unselected patients subjected to colonoscopy over a 3-year period were included in a prospective study. Biopsies were taken within 2 cm of the orifice of the appendix, from the caecum and from predefined colonic segments. Discontinuous inflammation of the appendiceal orifice was defined as an area of macroscopic inflammatory changes distinct from a normal caecum of ascending colon. The biopsies were graded histologically for the presence and severity of inflammation by a pathologist without knowledge of the endoscopic findings. Results. A total of 271 patients were included. The final diagnoses were: ulcerative colitis (UC) (83 patients), Crohn's disease (CD) (54), indeterminate colitis (12), irritable bowel syndrome (IBS) (54), microscopic colitis (15) and other disease (53). Endoscopic discontinuous inflammation of the appendiceal orifice was found in 27% (95% CI: 17-38%) of patients with UC, 24% (95% CI: 13-39%) with CD, 40% (95% CI: 12-74%) with indeterminate colitis, 8% (95% CI: 0-36%) with microscopic colitis, 10% (95% CI: 3-24%) of patients with IBS and in 9% (95% CI: 2-21%) of other diseases (p

Keywords: Appendiceal orifice inflammation; colonoscopy; inflammatory bowel disease; skip lesions; ulcerative colitis

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365520510023305

Affiliations: 1: Medical Department, Roskilde County Hospital, Køge, Denmark 2: Department of Pathology, Roskilde County Hospital, Roskilde, Denmark

Publication date: 2005-10-01

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