Authors: Rasmussen, Jeppe Grøndahl¹; Eschen, Rikke Bulow¹; Aardestrup, Inge Valbak¹; Dethlefsen, Claus¹; Griffin, Bruce²; Schmidt, Erik Berg¹

Source: Scandinavian Journal of Clinical and Laboratory Investigation, Volume 69, Number 1, February 2009 , pp. 156-160(5)

Publisher: Informa Healthcare

Abstract:

Objective . Endothelial dysfunction is a critical, prerequisite step in atherosclerosis, and may be evaluated by flow-mediated vasodilatation (FMD). The objective of this study was to examine interrelationships between FMD and plasma lipids and lipoproteins, and to determine the between-operator and within-subject variability associated with this technique. Material and methods. FMD, plasma lipids and lipoproteins, including small dense LDL (sdLDL), were measured twice in 40 healthy volunteers, 4 weeks apart. Interrelationships between mean FMD responses and plasma lipids and lipoproteins were examined by correlation analysis. FMD measurements were taken by two independent operators, allowing determination of between-operator variability. Within-subject variability was determined by obtaining two measurements, 4 weeks apart, in every subject, and carried out by the same operator. Results. FMD was inversely related to plasma triglycerides (r = -0.47, p = 0.002), total cholesterol/HDL cholesterol (r = -0.35, p = 0.03) and apolipoprotein B (r = -0.36, p = 0.02), but not to other plasma lipids and lipoproteins. When measuring variation in FMD, the following results were found: Between operators (SD = 4.0 FMD%) and within subjects (SD = 2.9 FMD%). Conclusions. The associations between FMD, plasma triglycerides and apoB provide evidence supporting a role for triglyceride-rich lipoproteins in endothelial dysfunction.

Keywords: Atherosclerosis; cholesterol; endothelium; lipoproteins; triglycerides

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365510802460474

Affiliations: 1: Department of Cardiology, Center for Cardiovascular Research Aalborg Hospital, Århus University Hospitals, Denmark 2: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK

Publication date: 2009-02-01

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