Authors: Soska, V.¹; Ciz, M.²; Kubala, L.²; Sobotova, D.³; Lojek, A.²

Source: Scandinavian Journal of Clinical and Laboratory Investigation, Volume 67, Number 3, 2007 , pp. 343-351(9)

Publisher: Informa Healthcare

Abstract:

Objective. Oxidative stress is one of the important complications occurring in haemodialysis. The aim of the study was to determine haemodialysis-induced changes in oxidative burst of phagocytes and the antioxidative properties of plasma. Methods. Twenty-seven patients and 50 healthy controls were examined. Oxidative burst of phagocytes and plasma antioxidative potential were measured luminometrically. Concentrations of major plasma antioxidants (vitamin E, bilirubin and uric acid) were also determined. Results. Phagocyte chemiluminescence was higher in patients before haemodialysis compared with that in controls and decreased after haemodialysis compared with predialysis status. A significant increase in plasma antioxidative potential and uric acid was found in patients before haemodialysis. These parameters decreased after haemodialysis compared with both predialysis and control values. Conclusions. The higher generation of phagocyte-derived oxidants and the decline in plasma antioxidative properties after haemodialysis confirm insufficient antioxidant defence in patients with chronic renal failure.

Keywords: Chemiluminescence; hematology; immunity; kidney diseases; markers of oxidative stress

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365510601120428

Affiliations: 1: Department of Clinical Biochemistry and Hematology, St. Ann's University Hospital, Masaryk University, Brno, Czech Republic 2: Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno, Czech Republic 3: 2nd Internal Department, St. Ann's University Hospital, Brno, Czech Republic

Publication date: 2007-01-01

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