Vascular endothelial growth factor serum concentrations in hypercholesterolemic patients

Authors: Trapé, J.¹; Morales, C.²; Molina, R.³; Filella, X.³; Marcos, J. M.⁴; Salinas, R.⁵; Franquesa, J.¹

Source: Scandinavian Journal of Clinical and Laboratory Investigation, Volume 66, Number 3, April 2006 , pp. 261-267(7)

Publisher: Informa Healthcare

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Abstract:

Objective . Vascular endothelial growth factor (VEGF) promotes normal and pathological angiogenesis. VEGF is a chemotactic factor for macrophages and vascular smooth muscle cells, and induces synthesis of metalloproteinases and adhesion molecules. VEGF expression is regulated by hypoxia, cytokines, oncogenes, and oxidized low‐density lipoprotein (LDL). The purpose of this study was to determine the relationship between levels of lipid parameters and VEGF, to investigate whether pravastatin treatment influences VEGF serum concentrations, and to examine the relationship between VEGF and the variations in post‐treatment lipid and inflammatory parameters. Material and methods . Eighteen patients aged 48±6.8 years with total cholesterol (TC) >6.1 mmol/L comprised the hypercholesterolemic group. The controls included 12 individuals aged 50±7.4 years with TC

Keywords: C‐reactive protein; growth factors; lipoproteins; statins; VEGF

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365510600564949

Affiliations: 1: Department of Laboratory Medicine 2: Lipid Unit 3: Department of Laboratory Medicine, Hospital Clinic de Barcelona, Spain 4: Department of Internal Medicine 5: Department of Hematology, Hospital de Sant Joan de Déu, Althaia Xarxa Assistencial de Manresa, Barcelona, Spain

Publication date: 2006-04-01

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