Cardiovascular risk factors in hemodialysis and peritoneal dialysis patients

Authors: Yilmaz, F. M.¹; Yilmaz, G.¹; Duranay, M.²; Parpucu, H.²; Şeneş, M.¹; Tekeli˙, N.²; Yücel, D.¹

Source: Scandinavian Journal of Clinical and Laboratory Investigation, Volume 65, Number 8, December 2005 , pp. 739-745(7)

Publisher: Informa Healthcare

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Abstract:

Background. Cardiovascular disease (CVD) is the major cause of mortality and morbidity of hemodialysis (HD) and peritoneal dialysis (CAPD) patients. We aimed to investigate the cardiovascular risk factors and their correlation with CVD in groups of HD and CAPD patients. Methods. Thirty HD patients, 30 CAPD patients and 30 healthy controls were included in the study. Apolipoprotein A‐l (apo A‐l), apolipoprotein B (apo B), apolipoprotein(a) [Lp(a)] and high‐sensitivity CRP (hs‐CRP) were measured with a Beckman Coulter nephelometer, and homocysteine (Hcy) was determined with an Agilent HPLC analyzer. Lipid profile was determined with a Synchron ® LX 20 Pro analyzer. Results. Hcy levels were 41.9±19.4, 41.8±38.5 and 9.3±3.5 µ mol/L; Lp(a) levels were 325±315, 431±367 and 130±97 mg/L; hs‐CRP levels were 3.78±3.21, 4.34±3.39 and 2.07±1.67 mg/L; apo A1/apo B ratios were 1.46±0.6, 1.36±0.5 and 1.80±0.59; total cholesterol levels were 3.56±0.7, 4.84±1.1 and 4.39±0.5 mmol/L; triglycerides were 1.44±0.5, 1.60±0.8 and 0.85±0.5 mmol/L in the HD, CAPD and control groups, respectively. Conclusion. HD and CAPD patients had higher Hcy, hs‐CRP and Lp(a) levels and lower apo A/B ratios than controls. There was no significant difference between the HD and CAPD groups. Hypertension, age and hs‐CRP showed a positive correlation with CVD.

Keywords: Apolipoprotein A‐l and B; apolipoprotein(a); cardiac risk; hemodialysis; homocysteine; hs‐CRP; peritoneal dialysis

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365510500375271

Affiliations: 1: Clinical Biochemistry Laboratory 2: Dialysis Unit of Ankara Hospital, Ministry of Health, Ankara, Turkey

Publication date: 2005-12-01

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