Plasma adiponectin is modestly decreased during 24-hour insulin infusion but not after inhibition of lipolysis by Acipimox

Authors: Dullaart, R. P. F.; Riemens, S. C.; Meinardi, J. R.; Wolffenbuttel, B. H. R.; Sluiter, W. J.

Source: Scandinavian Journal of Clinical and Laboratory Investigation, Volume 65, Number 6, 28Sep2005 , pp. 523-532(10)

Publisher: Informa Healthcare

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Abstract:

Objective . Plasma adiponectin is associated with insulin resistance and atherosclerosis. Adiponectin expression in adipose tissue is up-regulated by peroxisome proliferator-activated receptor (PPAR)- gamma

agonist treatment and its plasma level may be affected by insulin. We tested the hypothesis that prolonged exogenous insulin infusion decreases plasma adiponectin, and examined whether a possible effect of insulin on plasma adiponectin is attributable to inhibition of lipolysis. Material and methods . The effect of insulin infusion on plasma adiponectin (Linco enzyme-linked immunosorbent assay) was evaluated during a 24-h moderately hyperinsulinemic clamp (8.3 µU kg -1 s -1 ) in 8 male type 2 diabetic patients and in 8 healthy men. On a separate day, acipimox (250 mg/4 h for 24 h) was administered to inhibit lipolysis. Insulin and acipimox were administered in random order with 1 week between study days. Results . In type 2 diabetic patients, insulin infusion decreased plasma adiponectin from 7.74±2.53 mg/l to 6.76±2.41 mg/l after 24 h ( p

Keywords: Acipimox; adiponectin; free fatty acids; insulin; type 2 diabetes mellitus

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00365510500209090

Affiliations: 1: Department of Endocrinology, Groningen University Medical Center, The Netherlands

Publication date: 2005-09-28

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