Authors: Lunde, Søren¹; Smerup, Morten²; Hasenkam, J. Michael²; Sloth, Erik³

Source: Scandinavian Cardiovascular Journal, Volume 43, Number 4, August 2009 , pp. 267-272(6)

Publisher: Informa Healthcare

Abstract:

Objective.To develop a porcine model for Left Ventricular Hypertrophy (LVH) in which cardiac performance could be quantified non-invasively by Doppler ultrasound. Design. Sixteen 5 kg piglets were divided into two groups. In the first group (n=12) we performed an aortic banding and in the second group (n=4) a sham-operation. Endpoints were echo-assessed left ventricular midseptal and free-wall thickness, heart/body-weight ratio and cardiac myocyte diameter. Results.Free-wall thickness: 0.77±0.013 cm in the intervention group and 0.60±0.006 cm in the control group (p=0.015). Midseptal thickness: 0.79±0.015 cm in the intervention group and 0.58±0.010 cm in the control group (p=0.012). Heart/body-weight ratio: 7.73±0.970 in the intervention group and 6.23±0.430 in the control group (p=0.003). Cardiac myocyte diameter: 19.6±4.9 µm in the intervention group and 11.0±1.9 µm in the control group (p=0.000). Conclusion. A chronic porcine model for LVH has been established in which Doppler ultrasound can be used to quantify cardiac function non-invasively.

Keywords: Left ventricular hypertrophy; aortic stenosis; Doppler ultrasound; porcine model; minimal invasive

Document Type: Research article

DOI: http://dx.doi.org/10.1080/14017430802647389

Affiliations: 1: Department of Cardiothoracic & Vascular Surgery, Aarhus University Hospital, Skejby, Aarhus, Denmark,Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Skejby, Aarhus, Denmark 2: Department of Cardiothoracic & Vascular Surgery, Aarhus University Hospital, Skejby, Aarhus, Denmark 3: Department of Anesthesiology and Intensive Care, Aarhus University Hospital, Skejby, Aarhus, Denmark

Publication date: 2009-08-01

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