Changes in glycaemic control are related to the systolic function in type 1 diabetes mellitus

Authors: Andersen, Niels Holmark; Hansen, Troels Krarup; Christiansen, Jens Sandahl

Source: Scandinavian Cardiovascular Journal, Volume 41, Number 2, 2007 , pp. 85-88(4)

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Abstract:

Aim. To examine whether changes in glycaemic control are related to the left ventricular function, in a group of type 1 diabetic patients. Methods. We included 19 consecutive type 1 diabetic patients selected for insulin pump therapy due to poor metabolic control. The outcome measures were HbA1c and systolic left ventricular strain rate as measured by Tissue Doppler echocardiography. Mean follow-up period was 45 days (range 35-50). All patients included had an ejection fraction > 55%. None had cardiac symptoms. Results. The mean age of the participants was 40 years (range 22-65). Following initiation of insulin-pump therapy, the mean HbA1c improved significantly from 8.6±1.4% to 7.6±1.1% (p < 0.01). The mean strain rate of 16 myocardial segments also improved significantly, from -1.58±0.30 s-1 to -1.80±0.4 s-1 (p < 0.01). In addition, there was a significant correlation between the changes in left ventricular function and the changes in HbA1c (delta-Strain rate vs. delta-HbA1c: r = 0.49, p < 0.01). Conclusion. Changes in glycaemic control resulting from insulin pump therapy seem significantly related to the systolic function of the left ventricle.

Keywords: Echocardiography; diabetes; hyperglycaemia; congestive heart failure

Document Type: Research article

DOI: http://dx.doi.org/10.1080/14017430601156384

Affiliations: 1: Medical Department M (Diabetes & Endocrinology), Aarhus University Hospital, Denmark

Publication date: 2007-01-01

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