Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury

Authors: Li, Chun-Mei¹; Zhang, Xing-Hua¹; Ma, Xiao-Jing¹; Luo, Man²

Source: Scandinavian Cardiovascular Journal, Volume 40, Number 5, October 2006 , pp. 312-317(6)

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Abstract:

Objective. To test the hypothesis that limb ischemic postconditioning protects the myocardium from reperfusion injury, and examine the mechanism involved. Design. Forty rabbits were randomly divided into four groups: Control, Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning. Myocardial infarct size and tissue myeloperoxidase activity were determined at the end of the experiment. Plasma creatine kinase and malondialdehyde activity were measured at baseline, the end of ischemia, and after 3 h of reperfusion respectively. Results. Myocardial infarct size was significantly reduced in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning as compared to Control (p

Keywords: Remote postconditioning; ischemic postconditioning; ischemic preconditioning; ischemia-reperfusion injury; oxygen radicals

Document Type: Research article

DOI: http://dx.doi.org/10.1080/14017430600925292

Affiliations: 1: Department of Cardiology, Shandong Provincial Hospital of Shandong University, Jinan, 250021, China 2: Laboratory, Shandong University of Traditional Chinese Medicine, Jinan, 250014, China

Publication date: 2006-10-01

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