Mean arterial pressure about 40 mmHg during CPB is associated with cerebral ischemia in piglets

Authors: Haugen, Oddbjorn¹; Farstad, Marit¹; Lise Kvalheim, Venny²; Rynning, Stein-Erik²; Hammersborg, Stig¹; Mongstad, Arve²; Husby, Paul¹

Source: Scandinavian Cardiovascular Journal, Volume 40, Number 1, Number 1/February 2006 , pp. 54-61(8)

Publisher: Informa Healthcare

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Abstract:

Objective . To investigate if a mean arterial pressure below 50 mmHg during CPB may lead to cerebral ischemia. Material and methods . Piglets with low mean arterial pressure by nitroprusside (LP-group) (n?=?6) were compared with piglets given norepinephrine to obtain high pressure (HP-group) (n?=?6) during normothermic and hypothermic CPB. Intracranial pressure, flow and markers of cerebral energy metabolism (microdialysis) were recorded. Results . Mean arterial pressure differed significantly between the groups and stabilized about 40–45 mmHg in the LP-group. Cerebral perfusion pressure decreased to 21.3 (7.7) mmHg in the LP-group and increased to 51.8 (11.2) mmHg in the HP-group at 150 min of CPB (P?

Document Type: Research article

DOI: http://dx.doi.org/10.1080/14017430500365185

Affiliations: 1: Department of Surgical Sciences, Section for Anesthesiology and Intensive care, University of Bergen, Haukeland University Hospital, N-5021, Bergen, Norway 2: Department of Heart Disease, Section for Cardiothoracic Surgery, University of Bergen, Haukeland University Hospital, N-5021, Bergen, Norway

Publication date: 2006-02-01

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