Effects of the Arrabidaea chica extract on energy metabolism in the rat liver

Authors: de Souza, Alessandra Salvador1; Pagadigorria, Clairce Luzia Salgueiro1; Ishii-Iwamoto, Emy Luiza1; Bracht, Adelar1; Cortez, Diogenes Aparicio Garcia2; Yamamoto, Nair Seiko1

Source: Pharmaceutical Biology (Formerly International Journal of Pharmacognosy), Volume 47, Number 2, February 2009 , pp. 154-161(8)

Publisher: Informa Healthcare

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

The bignoniaceous Arrabidaea chica (Bonpl.) B. Verl. (syn. Bignonia chica), Bignoniaceae, popularly known as carajuru, puca panga, chica or pariri is very common in the Amazon region. Leaves of this plant are widely used as anti-inflammatory and astringent agents as well as remedies for intestinal colic, sanguine diarrhea, leucorrhea, anemia and leukemia. The action of the extract from leaves and stems of Arrabidaea chica on hepatic energy metabolism was investigated in the perfused rat liver and isolated mitochondria. In isolated mitochondria the Arrabidaea chica extract (0.25-1.25 mg/ml) decreased the respiratory coefficient with the substrates β-hydroxybutyrate and succinate. The activities of succinate-oxidase and NADH-oxidase were inhibited and the ATPase of intact mitochondria was stimulated. The extract also inhibited the glucose 6-phosphatase of isolated microsomes. The cellular content of glucose 6-phosphate was increased, while the level of ATP was reduced. In perfused livers the extract (0.25-1.0 mg/ml) caused stimulation of oxygen consumption, inhibition of gluconeogenesis from lactate and pyruvate and reduction of glucose release from endogenous glycogen. The results of this investigation suggest that the inhibitory effect of the extract on hepatic glucose production is mainly related to its actions on the mitochondrial energy metabolism.

Keywords: Arrabidaea chica; Bignoniaceae; liver; metabolism; mitochondria

Document Type: Research article

DOI: 10.1080/13880200802436281

Affiliations: 1: Laboratory of Liver Metabolism, Department of Biochemistry, University of Maringa, Maringa, Brazil 2: Laboratory of Pharmacognosy, University of Maringa, Maringa, Brazil

The full text article is not available for purchase.

The publisher only permits individual articles to be downloaded by subscribers.

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A