Authors: Saha, Achinta¹; Masud, Mohammad A.²; Bachar, Sitesh C.²; Kundu, Joydeb K.²; Datta, Bidyut K.²; Nahar, Lutfun³; Sarker, Satyajit D.⁴

Source: Pharmaceutical Biology (Formerly International Journal of Pharmacognosy), Volume 45, Number 5, June 2007 , pp. 355-359(5)

Publisher: Informa Healthcare

Abstract:

The petroleum ether, ethyl acetate, and methanol extracts of Phyllanthus reticulatus Poir. (Euphorbiaceae) were chosen for pharmacological screening. In the acetic acid-induced writhing test, the ethyl acetate extract in doses of 150 and 300 mg/kg showed 51.23 and 65.12% inhibition of writhing, respectively. A significant elongation of tail-flick time was evident both in the ethyl acetate and the methanol extracts (42.38 and 60.49%) only at the 300 mg/kg dose level. In carrageenan-induced rat paw edema model, the methanol extract at the 300 mg/kg dose level showed 40.03% inhibition of edema at the end of 4 h. These results demonstrated that the extracts of P. reticulatus possess significant analgesic and anti-inflammatory properties.

Keywords: Acetic acid-induced writhing response; anti-inflammatory; carrageenan-induced rat paw edema assay; Euphorbiaceae; Phyllanthus reticulatus; radiant heat tail-flick method

Document Type: Research article

DOI: http://dx.doi.org/10.1080/13880200701212973

Affiliations: 1: Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka, Bangladesh 2: Department of Pharmaceutical Technology, University of Dhaka, Dhaka, Bangladesh 3: Department of Chemistry, University of Aberdeen, Aberdeen, Scotland, UK 4: School of Biomedical Sciences, University of Ulster at Coleraine, Cromore Road, Coleraine, County Londonderry, Northern Ireland, UK

Publication date: 2007-06-01

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