Peculiar Findings in a Case of Bilateral Uveal Pigmented Lesions
Source: Ocular Immunology and Inflammation, Volume 18, Number 5, October 2010 , pp. 379-382(4)
Publisher: Informa Healthcare
Abstract:Purpose: To describe a probable case of bilateral diffuse uveal melanocytic proliferation (BDUMP) with unusual manifestations and prognosis.
Design: Case report.
Methods: Clinical follow-up of the patient lasting 50 months with recurrent fundus examination using color photographs, angiography, ultrasound, and optical coherence tomography. Serological and radiological investigations were performed to assess possible extraocular alterations.
Results: In both eyes patch-shaped pigmented alterations of the fundus were revealed. Fluorescein and indocyanine angiography evidenced corresponding areas of hyperfluorescent pinpoints and subtle serous detachment of the neurosensory retina, respectively. Ten months after the initial evaluation, flat pigmentary lesions appeared in the superior scleral surface of the right eye and underwent histological examination. After an initial decrease in visual acuity, the patient experienced a spontaneous recovery. He did not develop cataracts or any systemic malignancies.
Conclusions: Although not all the criteria for the diagnosis were fulfilled, clinical findings were compatible with BDUMP. The presence of scleral pigmented lesions and the good visual prognosis may widen the spectrum of this rare disease.
Document Type: Research Article
Affiliations: 1: 1Institute of Ophthalmology, University of Parma, Parma, Italy 2: 2Pathology Department, University of Parma, Parma, Italy 3: 3“Jules Gonin” Ophthalmic Hospital, University of Lausanne, Lausanne, Switzerland
Publication date: October 2010