Vogt-Koyanagi-Harada Syndrome in Children: Report of a Case and Review of the Literature
Authors: Berker, Nilufer; Ozdamar, Yasemin; Soykan, Emel; Ozdal, Pinar; Ozkan, Seyhan Sonar
Source: Ocular Immunology and Inflammation, Volume 15, Number 4, July 2007 , pp. 351-357(7)
Publisher: Informa Healthcare
Abstract:This article reviews the therapeutic approaches in children with Vogt-Koyanagi-Harada (VKH) syndrome, and reports on a 9-year-old girl with progressive visual loss due to VKH syndrome in spite of treatment. In previous reports, corticosteroids were found to be the most effective agents in the treatment of VKH syndrome, while combination therapies with cyclosporine, methotrexate, or azathioprine were used with favorable results in refractory cases. In the current case, none of the treatments sufficiently stabilized the vision, but triple combination of corticosteroids, cyclosporine, and methotrexate suppressed the relapses of intraocular inflammation. Treatment of children with VKH syndrome is challenging. Various treatment modalities have been reported with various responses, but there is still no definite treatment regimen, and the treatment is usually individualized in pediatric VKH cases.
Document Type: Research Article
Affiliations: Department of Retinal and Uveal Diseases, Ulucanlar Eye Research Hospital, Ankara, Turkey
Publication date: July 1, 2007