Plasma IL-4, IL-8, IL-12, interferon-γ and CRP levels in pregnant women with preeclampsia, and their relation with severity of disease and fetal birth weight
Source: Journal of Maternal-Fetal and Neonatal Medicine, Volume 25, Number 9, September 2012 , pp. 1569-1573(5)
Publisher: Informa Healthcare
Abstract:Objective: The aim of the present study was to evaluate the hypothesis that preeclampsia is associated with increased systemic inflammatory responses of Th1-type as well as decreased Th2-type responses compared with normal pregnancy. We also sought to determine whether there was a correlation between these markers with severity of preeclampsia and fetal birth weight. Methods: The study population consisted of maternal age, gestational age, and body mass index matched 138 pregnant women; 56 normotensive healthy pregnant women (group 1), 42 women with mild preeclampsia (group 2), 40 women with severe preeclampsia (group 3). Results: Plasma interleukin (IL)-8 and C-reactive protein (CRP) levels were significantly higher in group 3 than group 1 (p < 0.05). Plasma IL-4, IL-12, and interferon (IFN)-γ levels were similar in all groups. Although plasma IL-8 and CRP levels of mild preeclamptic group were higher than control group and lower than severe preeclamptic group, the differences were not statistically significant. There was a positive correlation between IL-12 and fetal birth weight in severe preeclamptic group (p < 0.05). Conclusions: Elevated maternal serum pro-inflammatory cytokine IL-8 and CRP in severe preeclamptic women compared with normal pregnant women supports the hypothesis that preeclampsia is associated with increased inflammatory responses.
Document Type: Research Article
Affiliations: 1: 1Department of Obstetrics and Gynecology, Kahramanmaras Sutcuimam University Medical Faculty, Kahramanmaras, Turkey 2: 2Department of Microbiology, Kahramanmaras Sutcuimam University Medical Faculty, Kahramanmaras, Turkey 3: 3Department of Public Health, Kahramanmaras Sutcuimam University Medical Faculty, Kahramanmaras, Turkey
Publication date: September 1, 2012