Human cytomegalovirus infection and clinical status of infants born to human immunodeficiency virus type 1 infected mothers

Authors: Mania, Anna1; Kemnitz, Pawełł1; Mazur-Melewska, Katarzyna1; Figlerowicz, Magdalena1; Cudnoch, Kamila1; Słłużżewski, Wojciech1; Kowala-Piaskowska, Arleta2; Mozer-Lisewska, Iwona2

Source: Journal of Maternal-Fetal and Neonatal Medicine, Volume 25, Number 2, February 2012 , pp. 180-186(7)

Publisher: Informa Healthcare

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Abstract:

Objective. Human cytomegalovirus (HCMV) is one of the most common congenital infections worldwide and a frequent opportunistic infection that aggravates the condition of human immunodeficiency virus (HIV)-infected patients. The aim of the study was to evaluate the frequency and factors influencing HCMV infection among infants of HIV-positive women.

Methods. The study included 35 infants born to HIV-1-infected mothers examined for congenital infections. Children were evaluated for human immunodeficiency virus type 1 (HIV-1), HCMV, and HCV infection by serological and molecular methods.

Results. HIV-1 infection was found in one child whose mother did not receive antiretroviral treatment during pregnancy, and HCV infection in another infant. HCMV-DNA in the urine was present in 13/35 infants (37.14%%) on the 10th day and 24/35 infants (68.57%%) in the 4th week of life. The majority of HCMV-infected infants were asymptomatic, although they manifested microcephaly and low birth weight significantly more frequently (p == 0.006 and p == 0.02, respectively). Type HIV prophylaxis did not influence HCMV transmission.

Conclusions. Although often asymptomatic, HCMV infection in infants born to HIV-infected mothers is frequent and may be associated with prematurity, low birth weight, and microcephaly. Diagnostic procedures in children of HIV-infected mothers should involve HCMV.

Keywords: HCMV infection; HIV-infected women; infants

Document Type: Research Article

DOI: http://dx.doi.org/10.3109/14767058.2011.568550

Affiliations: 1: 1Department of Infectious Diseases and Child Neurology, University of Medical Sciences, Poznańń, Poland 2: 2Department of Infectious Diseases, University of Medical Sciences, Poznańń, Poland

Publication date: February 1, 2012

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