Preeclampsia and pregnancies with small-for-gestational age neonates have different profiles of complement split products

Authors: Soto, Eleazar; Romero, Roberto; Richani, Karina1; Espinoza, Jimmy; Chaiworapongsa, Tinnakorn; Nien, Jyh Kae; Edwin, Sam S.1; Kim, Yeon Mee1; Hong, Joon Seok2; Goncalves, Luis F.; Yeo, Lami; Mazor, Moshe3; Hassan, Sonia S.; Kusanovic, Juan Pedro

Source: Journal of Maternal-Fetal and Neonatal Medicine, Volume 23, Number 7, July 2010 , pp. 646-657(12)

Publisher: Informa Healthcare

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Abstract:

Objective. The activation of the complement system results in the generation of split products with pro-inflammatory properties. The objective of this study was to determine whether preeclampsia and small-for-gestational age (SGA) are associated with changes in the maternal plasma concentrations of anaphylatoxins C3a, C4a and C5a.

Methods. A cross-sectional study was conducted in the following groups: (a) normal pregnant women (n = 134); (b) women who delivered an SGA neonate (n = 53); (c) preeclampsia with (n = 52) and without SGA (n = 54). Maternal plasma anaphylatoxin concentrations were determined by enzyme-linked immunoassay.

Results. (1) Women with preeclampsia with or without SGA had a significantly higher median plasma C5a concentration than that of normal pregnant women and those with SGA alone (all P < 0.01); (2) women with SGA alone did not have an increase in plasma C5a concentration; (3) in contrast, the median maternal plasma concentration of C4a was lower in women with preeclampsia and SGA than that of those with a normal pregnancy (P = 0.001); (4) no changes in C3a were observed among the study groups.

Conclusion. Preeclampsia is associated with increased plasma concentration of C5a, regardless of the presence or absence of an SGA fetus. In contrast, there was no difference in the plasma C3a, C4a and C5a concentration in patients with SGA.

Keywords: C3a; C4a; C5a; Complement system; SGA; anaphylatoxins; hypertension; inflammation; innate immunity; pregnancy

Document Type: Research Article

DOI: http://dx.doi.org/10.3109/14767050903301009

Affiliations: 1: 1Perinatology Research Branch, NICHD/NIH/DHHS, Bethesda, Maryland, USA 2: 4Department of Obstetrics and Gynecology, Seoul National University, Seoul, Korea 3: 5Department of Obstetrics and Gynecology, Ben Gurion University of the Negev, Beer-Sheva, Israel

Publication date: July 1, 2010

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