Plasma endothelin-1 and atrial natriuretic peptide levels during prolonged (24-h) non-acidemic hypoxemia in fetal goats
Authors: Yamada, J.; Fujimori, K.; Ishida, T.; Sanpei, M.; Honda, S.; Sato, A.
Source: Journal of Maternal-Fetal Medicine, Volume 10, Number 6, 1 December 2001 , pp. 409-413(5)
Publisher: Informa Healthcare
Abstract:Objective: The purpose of this study was to investigate the effects of prolonged (24-h) non-acidemic hypoxemia on plasma endothelin-1 and atrial natriuretic peptide (ANP) in fetal goats.
Methods: During continuous infusion of nitrogen into the maternal trachea, fetal plasma endothelin-1 and ANP levels were measured in nine chronically instrumented goat fetuses at 117–129 days' gestation. Endothelin-1 and ANP were measured by radioimmunoassay.
Results: Fetal arterial pO2 decreased significantly from 23.1 ± 1.0 mmHg (control) to 15.2 ± 0.9 mmHg during the first 2 h of hypoxemia and to 15.7 ± 1.1 mmHg at the end of the experimental period of hypoxemia. The plasma endothelin-1 concentration increased from 10.6 ± 1.9 pg/ml to 20.4 ± 4.3 pg/ml (p < 0.05) during the first 2 h and was 19.7 ± 2.4 pg/ml (p < 0.01) at the end of the experimental period. The plasma ANP concentration also increased, from 20.3 ± 5.5 pg/ml to 23.0 ± 4.7 pg/ml in the first 2 h and then to 58.0 ± 8.8 pg/ml (p < 0.05) at the end of the experimental period. There was a significant negative correlation between fetal plasma endothelin-1 and pO2, but no significant correlation was found between fetal plasma ANP and pO2.
Conclusions: Prolonged non-acidemic hypoxemia induces a continuous increase in fetal plasma endothelin-1 and ANP levels. Fetal plasma ANP increases time-dependently but endothelin-1 remains constant during hypoxemia.
Document Type: Original Article
Affiliations: Department of Obstetrics and Gynecology, School of Medicine, Fukushima Medical University, Fukushima City, Fukushima, Japan
Publication date: 1 December 2001