FIZZ1 Plays a Crucial Role in Early Stage Airway Remodeling of OVA-Induced Asthma

Authors: Dong, Liang¹; Wang, Shu-Juan¹; Camoretti-Mercado, Blanca²; Li, Hong-Jia¹; Chen, Ming¹; Bi, Wen-Xiang³

Source: Journal of Asthma, Volume 45, Number 8, October 2008 , pp. 648-653(6)

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Abstract:

The aim of this study was to elucidate the role of Found in Inflammatory Zone 1 (FIZZ1, also known as RELM-α or resistin-like molecule-α) in airway remodeling in asthma. We used a rat model of ovalbumin (OVA) sensitization and challenge to induce lung inflammation and remodeling. Expression of α -SMA in the lungs of OVA-treated rats was significantly elevated in the peribronchial regions compared with control saline-treated animals. Expression of FIZZ1 mRNA in alveolar epithelial type II cells (AECII) isolated from OVA-treated animals was higher than in control animals. Forced expression of recombinant FIZZ1 in rat-1 lung fibroblast cell line enhanced production of collagen type I and α -SMA compared with control transfected cells. These results suggest that FIZZ1 can induce fibroblasts to express markers of myofibroblast differentiation such as α -SMA and collagen type I, which are characteristic of early stages of airway remodeling seen in asthma.

Keywords: FIZZ1; found in inflammatory zone 1; asthma; α-smooth muscle actin; type I collagen; airway remodeling

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02770900802126941

Affiliations: 1: Department of Pulmonary Diseases, Qilu Hospital of Shandong University, Jinan, Shandong, China 2: Pulmonary, Department of Medicine, The University of Chicago, Chicago, USA 3: Department of Biochemistry, School of Medicine, Shandong University, Jinan, Shandong, China

Publication date: 2008-10-01

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