Authors: Bernstein, Jonathan¹; Bobbitt, R.¹; Levin, Linda²; Floyd, Roger¹; Crandall, Michael³; Shalwitz, Robert⁴; Seth, Anand⁴; Glazman, Mark⁴

Source: Journal of Asthma, Volume 43, Number 4, May 2006 , pp. 255-262(8)

Publisher: Informa Healthcare

Abstract:

Objective. Centrally installed ultraviolet (UV) irradiation units were investigated to determine the potential health benefits in mold-sensitized asthmatic children.    Methods. Nineteen mold-sensitized asthmatic children 5 to 17 years of age with home central ventilation systems were enrolled in a 28-week double-blinded placebo controlled cross-over trial. Clinical outcome measurements included morning and evening peak expiratory flow rates (PEFR), PEFR variability, change in forced expiratory volume in 1 second (FEV 1 ), change in total rhinoconjunctivitis and asthma symptom scores, change in rhinoconjunctivitis and asthma quality-of-life scores, and total (rescue and controller) medication use from baseline and between time periods. Environmental outcomes included changes in temperature, relative humidity, dew point, and indoor airborne mold and bacterial counts from baseline and between time periods. Analysis of variance (ANOVA) and regression analysis and t test were used to evaluate relationships between environmental exposure(s) and clinical outcome measurements during each study period.    Results. Twelve male and seven female children, average age 10.6 years, were enrolled. A statistically significant improvement in PEFR variability in subjects receiving CREON2000 units followed by placebo units was observed ( p

Keywords: ultraviolet irradiation; CREON2000; asthma; rhinoconjunctivitis; quality of life; mold exposure; bacteria exposure; health effects

Document Type: Research article

DOI: http://dx.doi.org/10.1080/02770900600616887

Affiliations: 1: Department of Internal Medicine, Division of Immunology, Allergy Section, Cincinnati, Ohio, USA 2: Department of Environmental Health, Epidemiology and Biostatistics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA 3: Indoor Environmental Services, Cincinnati, Ohio, USA 4: General Innovations and Goods, Inc., Columbus, Ohio, USA

Publication date: 2006-05-01

More about this publication?

• Information for Authors
• Subscribe to this Title
• Terms & Conditions
• ingentaconnect is not responsible for the content or availability of external websites

Related content

• In this: publication
• By this: publisher
• By this author: Bernstein, Jonathan ;  Bobbitt, R. ;  Levin, Linda ;  Floyd, Roger ;  Crandall, Michael ;  Shalwitz, Robert ;  Seth, Anand ;  Glazman, Mark

Website © Publishing Technology. Article copyright remains with the publisher, society or author(s) as specified within the article.

• Terms and conditions
• Privacy policy
• Information for advertisers