The Capability of Glucose Toxicity on Severe Type 2 Diabetes

Authors: Hsieh, Chang-Hsun1; Hung, Yi-Jen1; He, Chih-Tseung1; Lee, Chien-Hsing1; Hung, Szu-Chun2; Wang, Yi-Kuan3; Kuo, Shi-Wen4; Pei, Dee4

Source: Endocrine Research, Volume 31, Number 2, 2005 , pp. 149-158(10)

Publisher: Informa Healthcare

Buy & download fulltext article:

OR

Price: $42.29 plus tax (Refund Policy)

Abstract:

The underlying defects of type 2 diabetes are impaired insulin sensitivity and decreased beta-cell function. In poorly controlled type 2 diabetes, the ‘glucose toxicity' further deteriorates these defects. The objective was to determine whether correction of glucose toxicity will lead to improve insulin sensitivity and beta-cell function in these severely affected patients. Twelve severe type 2 diabetic patients were enrolled. An intravenous glucose tolerance test was performed before and after treatment with insulin for 3 months. The insulin sensitivity, glucose sensitivity, and acute insulin response after glucose loading were calculated by a minimal model algorithm. The lipid profiles did not change significantly after insulin therapy, but the hemoglobin A 1c level improved significantly (12.2 ± 2.2% to 9.2 ± 1.9%; p = 0.001). The insulin sensitivity, glucose sensitivity, and acute insulin response did not change significantly with insulin therapy. Correction of hyperglycemia with 3-month insulin therapy may improve metabolic effect instead of insulin sensitivity, glucose sensitivity, and acute insulin response to glucose load in severe type 2 diabetic patients.

Keywords: Acute insulin response; Glucose sensitivity; Glucose toxicity; Insulin sensitivity; Intravenous glucose tolerance test

Document Type: Research article

DOI: http://dx.doi.org/10.1080/07435800500320661

Affiliations: 1: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan, Republic of China 2: Division of Nephrology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei, Taiwan, Republic of China 3: Nursing Department, Buddhist Tzu Chi General Hospital, Taipei, Taiwan, Republic of China 4: Division of Endocrinology and Metabolism, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei, Taiwan, Republic of China

Publication date: 2005-01-01

More about this publication?
Related content

Key

Free Content
Free content
New Content
New content
Open Access Content
Open access content
Subscribed Content
Subscribed content
Free Trial Content
Free trial content

Text size:

A | A | A | A
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages. print icon Print this page