Antifungal Activity of the Essential oil of Thymus vulgaris L. and Thymol on Experimentally Induced Dermatomycoses
Source: Drug Development and Industrial Pharmacy, Volume 34, Number 12, December 2008 , pp. 1388-1393(6)
Publisher: Informa Healthcare
Abstract:The in vivo evaluation of the toxicological and antifungal activity of the essential oil of Thymus vulgaris L. and its main component thymol was made on 2-month-old male Wistar rats. We examined the therapeutic potency against experimentally induced dermatomycoses in rats, using the most frequent dermatomycetes, Trichophyton mentagrophytes, T. rubrum, and T. tonsurans. The therapeutic efficacy of a 1% solution of the essential oil of Thymus vulgaris and thymol as well as the commercial preparation bifonazole was evaluated. During the 37-day observation period the oil-treated animals were cured.
Document Type: Research Article
Affiliations: 1: Institute for Biological Research, “S. Stankovic,” Bulevar despota Stefana, Belgrade, Serbia 2: Institute of Botany and Botanical Garden “Jevremovac,” Faculty of Biology, Studentski trg, University of Belgrade, Belgrade, Serbia 3: Janssen-Cilag, Department of Johnson-Johnson S.E., Bulevar Mihajla Pupina, Belgrade, Serbia
Publication date: 2008-12-01