The toxic effect of different concentrations of povidone iodine on the rabbit's cornea

Authors: Jiang, Jin; Wu, Miaoqin; Shen, Ting

Source: Cutaneous and Ocular Toxicology (formerly Journal of Toxicology - Cutaneous and, Volume 28, Number 3, February 2009 , pp. 119-124(6)

Publisher: Informa Healthcare

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Abstract:

Objectives: To investigate the effects of polyvinylpyrrolidone (i.e., povidone) iodine (PVP-I) in different concentrations on the rabbit's cornea. Methods: PVP-I in various concentrations was instilled into the conjunctival sac and injected into the anterior chamber independently. The toxicity to the cornea was assessed by fluorescence dye, specular microscopy, and corneal pachymetry. Results: After conjunctival sac PVP-I instillation, severe epithelial damage was observed at the concentrations of 5.0% and 2.5%. After anterior chamber PVP-I injection, significant corneal edema was observed at the concentrations of 2.0% and 1.5%. Conclusions: It can be safe and feasible to use 0.5% or 1.0% concentrations of PVP-I in conjunctival sac instillation for preoperative antisepsis.

Document Type: Research article

DOI: http://dx.doi.org/10.1080/15569520903080511

Affiliations: 1: 1Department of Ophthalmology, Zhejiang Provincial People's Hospital, Hangzhou, China

Publication date: 2009-02-01

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