The Mean Platelet Volume and Atherogenic Index of Plasma in Nondipper Normotensive Individuals Compared to Dippers

Authors: Yildiz, Gürsel1; Hür, Ender2; Özçiçek, Adalet3; Candan, Ferhan4; Kayatas, Mansur4

Source: Clinical and Experimental Hypertension, Volume 35, Number 1, February 2013 , pp. 35-39(5)

Publisher: Informa Healthcare

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Mean platelet volume (MPV) is a determinant of platelet activation. Atherogenic index of plasma (AIP), which is defined as the logarithm of the ratio of plasma level of triglycerides to the level of high-density lipoprotein (HDL)-cholesterol (log[ TG/HDL-C]), has recently been used as a marker of atherogenicity. This study included 104 normotensive individuals. Mean platelet volume and AIP were measured in all patients. Nondipper individuals (8.6 ± 0.9 fL, 0.3 ± 0.2) demonstrated higher values of MPV and AIP compared with dippers (7.9 ± 1.1 fL, 0.1 ± 0.2) (P < .001 and < .001, respectively). Mean platelet volume and AIP have a positive correlation with insufficient decline in nocturnal blood pressure.

Keywords: atherogenic index of plasma; dippers; mean platelet volume; nondippers; normotensive

Document Type: Research Article


Affiliations: 1: 1Atatürk State Hospital, Clinic of Nephrology, Zonguldak, Turkey 2: 2Division of Nephrology, Department of Internal Medicine, School of Medicine, Karaelmas University, Zonguldak, Turkey 3: 3Department of Internal Medicine, School of Medicine, Erzincan University, Erzincan, Turkey 4: 4Division of Nephrology, Department of Internal Medicine, School of Medicine, Cumhuriyet University, Sivas, Turkey

Publication date: February 1, 2013

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