Authors: Ueno, Mai¹; Tamura, Yuki¹; Toda, Natsuko¹; Yoshinaga, Mariko¹; Terakado, Shouko¹; Otsuka, Kie¹; Numabe, Atsushi²; Kawabata, Yukari³; Murota, Itsuki⁴; Sato, Nobuyuki⁴; Uehara, Yoshio¹

Source: Clinical and Experimental Hypertension, Volume 34, Number 5, August 2012 , pp. 305-310(6)

Publisher: Informa Healthcare

Abstract:

We investigated the effects of sodium alginate oligosaccharides (alginate) on the development of spontaneous hypertension in rats. Spontaneous hypertensive rats were treated with alginate for 7 weeks. Systolic blood pressure (SBP) and cardiovascular and kidney damage were assessed. Systolic blood pressure increased in SHRs and this elevation was attenuated with alginate treatment. The heart weight tended to decline. Alginate did not change plasma cholesterol levels or urinary sodium excretions. The slightly higher urinary protein excretion in SHRs was not changed with the treatment; however, morphologic glomerular damage was significantly attenuated. Sodium alginate oligosaccharide attenuates spontaneous hypertension in SHRs, and may help prevent early-stage kidney injury.

Keywords: alginate; food fibers; spontaneously hypertensive rats (SHRs); salt-induced hypertension; kidney

Document Type: Research article

DOI: http://dx.doi.org/10.3109/10641963.2011.577484

Affiliations: 1: 1Department of Clinical Nutrition, Kyoritsu Women's University, Tokyo, Japan 2: 2Department of Clinical and Laboratory Medicine, Dokkyo University School of Medicine, Mibu, Japan 3: 3Heath Service Center, University of Tokyo, Tokyo, Japan 4: 4Central Research Institute, Maruha Nichiro Holdings, Inc., Tsukuba, Japan

Publication date: 2012-08-01

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