Successful treatment of perforating granuloma annulare with 0.1% tacrolimus ointment

Authors: Lopez-Navarro, Norberto¹; Castillo, Rosa¹; Gallardo, MarIa¹; Alcaide, Antonio¹; Matilla, Alfredo²; Herrera, Enrique¹

Source: Journal of Dermatological Treatment, Volume 19, Number 6, November 2008 , pp. 376-377(2)

Publisher: Informa Healthcare

Buy & download fulltext article:

Price: $33.39 plus tax (Refund Policy)

Abstract:

Perforating granuloma annulare (PGA) is a rare subtype of granuloma annulare (GA) named in 1971 by Owens and Freeman. It is characterized by necrobiotic areas surrounded by histiocytes and lymphocytes with transepidermal elimination. Many treatments for PGA have been used, often with unsatisfactory results. Tacrolimus in its topical formulation has been established as a safe and effective alternative to topical corticosteroids because of its mild side effects and its minimal systemic absorption. Topical tacrolimus has been approved for the treatment of atopic dermatitis; moreover, ample data exist which demonstrate the usefulness of tacrolimus for the specific treatment of other inflammatory diseases. We report a 70-year-old diabetic woman with PGA, in whom the ulceration due to PGA responded to 0.1% topical tacrolimus.

Keywords: Perforating granuloma annulare; tacrolimus; treatment

Document Type: Research article

DOI: http://dx.doi.org/10.1080/09546630802132650

Affiliations: 1: Department of Dermatology, 2: Department of Pathology, University Hospital, School of Medicine, Malaga, Spain

Publication date: 2008-11-01

More about this publication?