Treatment and follow-up of persistent granulomatous cheilitis with intralesional steroid and metronidazole

Authors: B Coskun¹; Y Saral¹; D Cicek¹; N Akpolat²

Source: Journal of Dermatological Treatment, Volume 15, Number 5, September 2004 , pp. 333-335(3)

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Abstract:

Granulomatous cheilitis (GC) is a chronic edema which frequently affects the upper lip due to granulomatous inflammation. Its etiology is currently unknown. This rare disease is generally accompanied by Melkersson-Rosenthal syndrome (MRS), characterized by scrotal tongue, orofacial edema and facial paralysis. However, it is also known to develop only with orofacial edema. Granulomatous cheilitis is a difficult disease to treat because of recurrences. There are contradictory reports about the results of treatment without surgical intervention and the rates of recurrence. Our case was a 57-year-old female patient who was characterized by orofacial edema only. The edema and erythema had persisted for 1 year before admission. In the present case, application of intralesional corticosteroid treatment as a total of three injections over 3 consecutive months (one injection per month) and the accompanying metronidazole treatment brought about successful results. No recurrence was observed in the follow-up.

Keywords: Granulomatous cheilitis; Intralesional corticosteroid; Melkersson-Rosenthal syndrome; Metronidazole

Document Type: Research article

DOI: http://dx.doi.org/10.1080/09546630410015538

Affiliations: 1: Dermatology 2: Pathology Firat University Faculty of Medicine Elazig Turkey

Publication date: 2004-09-01

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