Successful treatment of pyoderma gangrenosum with topical 0.5% nicotine cream

Authors: GK Patel¹; JR Rhodes²; B Evans³; PJA Holt¹

Source: Journal of Dermatological Treatment, Volume 15, Number 2, April 2004 , pp. 122-125(4)

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Abstract:

Pyoderma gangrenosum is potentially a devastating and destructive disorder. There is no uniformly effective or specific therapy for pyoderma gangrenosum. Previous reports of nicotine therapy for pyoderma gangrenosum have suggested it to be efficacious. Unfortunately, previous reports were restricted by the use of commercially available preparations of nicotine, either as a gum or patch formulation. We have used topical nicotine 0.5% w/w cetamacrogol formula A cream that enables direct application onto the lesion, as well as dose and concentration variation. Two patients with pyoderma gangrenosum treated with topical nicotine 0.5% w/w cetamacrogol formula A cream are described here, both of whom had dramatic clinical resolution of their pyoderma gangrenosum.

Keywords: Pyoderma gangrenosum; Topical nicotine cream; Treatment

Document Type: Research article

DOI: http://dx.doi.org/10.1080/09546630310019364

Affiliations: 1: Department of Dermatology 2: Gastroenterology University Hospital of Wales Heath Park Cardiff UK 3: St Mary's Pharmaceutical Unit Penarth Vale of Glamorgan UK

Publication date: 2004-04-01

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