Comparison of Retinal Degeneration in the Normal Goldfish and the Megalophthalmic Black Moor Goldfish after Optic Nerve Transection and Lens Extraction

Authors: Ying, Xi¹; Wai, Maria²; Wang, Yi¹; Lau, Jeanie²; Forster, Elizabeth Lucy²; Yew, David²

Source: International Journal of Neuroscience, Volume 119, Number 5, May 2009 , pp. 744-753(10)

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Abstract:

A comparison in retinal degeneration was studied in the normal goldfish and the megalophthalmic goldfish after optic nerve transection or lens extraction by the TUNEL (Terminal transferase-mediated dUTP nick end labeling) technique. A significant number of TUNEL positive cells appeared in both cases 7 days after injury, with a more prominent result in the megalophthalmic eye. Lens extraction, had less apoptotic cell death in the experimental retinas.

Keywords: goldfish; lens extraction; megalophthalmic; normal; optic nerve transection; retina

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00207450802325694

Affiliations: 1: Department of Ophthalmology, Southwest Hospital, Third Military Medical University, Chongqing, China 2: Department of Anatomy, Chinese University of Hong Kong, Shatin, N.T. Hong Kong, China

Publication date: 2009-05-01

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