Postmortem MRI Changes of the Brains of the Rats of Different Ages

Authors: Xu, Jie¹; Zou, Yan²; Zhang, Li-Hong³; Wai, Maria Sen Mun³; Kung, Hsiang-Fu⁴; Ge, Zhen-Ying¹; Yew, David³

Source: International Journal of Neuroscience, Volume 118, Number 7, July 2008 , pp. 1039-1050(12)

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Abstract:

Brain degenerative changes were studied in the rats of different ages after cervical dislocation by T2 MRI and histology. Appearance of dark spots in the T2 images increased with increased duration after death. Quantitative analysis of the density of these spots revealed that the neonatal (1 week) and the old (9 months) animals had accelerated degenerative changes when compared with the young adult (1 month). The degenerative changes correlated with the accumulation of vacuoles or spaces in the brain tissue histologically. This study pointed out not only brain degenerative changes after death were associated with age, it also revealed that the MRI T2 evaluations could be used as a way in postmortem investigation.

Keywords: age; brain; degeneration; postmortem; T2 MRI

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00207450701769141

Affiliations: 1: Department of Anatomy, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China 2: Department of Radiology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China 3: Department of Anatomy, Chinese University of Hong Kong, Shatin, N.T., Hong Kong 4: Stanley Ho Centre for Emerging Infectious Diseases, School of Public Health, Chinese University of Hong Kong, Shatin, N.T., Hong Kong

Publication date: 2008-07-01

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