ENDOTHELIN-1-INDUCED CEREBRAL ISCHEMIA: EFFECTS OF KETANSERIN AND MK-801 ON LIMB PLACING IN RATS

Authors: Moyanova, S.; Kortenska, L.; Mitreva, R.

Source: International Journal of Neuroscience, Volume 117, Number 9, September 2007 , pp. 1361-1381(21)

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Abstract:

The long-term effects of the 5-HT2A receptor antagonist ketanserin on deficits in sensorimotor integration (limb placing tests) following transient focal cerebral ischemia in rats were compared to the effects of the NMDA antagonist MK-801. Middle cerebral artery occlusion was induced in conscious rats by microinjection of endothelin-1 in the vicinity of the artery (EMCAO model). The EMCAO/vehicle rats exhibited impaired tactile and proprioceptive limb placing. In contrast to ketanserin, MK-801 exerted severe early behavioral disturbances, but both drugs significantly improved the neurological scores much earlier than the spontaneous recovery of function occurred. The present results suggest that pharmacotherapy by means of ketanserin lacking the severe side effects of the NMDA antagonists can be used to enhance functional recovery after stroke.

Keywords: 5-HT2 receptor; Endothelin-1 model of brain ischemia; middle cerebral artery occlusion; neurological deficit; NMDA receptor

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00207450600938847

Affiliations: 1: Bulgarian Academy of Sciences Department of Neurobiology of Adaptation, Institute of Neurobiology, Sofia, Bulgaria

Publication date: 2007-09-01

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