STEREOTYPIC CIRCLING BEHAVIOR IN MICE WITH VESTIBULAR DYSFUNCTION: ASYMMETRICAL EFFECTS OF INTRASTRIATAL MICROINJECTION OF A DOPAMINE AGONIST

Authors: Ishiguro, Akio¹; Inagaki, Masumi²; Kaga, Makiko²

Source: International Journal of Neuroscience, Volume 117, Number 7, July 2007 , pp. 1049-1064(16)

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Abstract:

Bronx Waltzer (bv) mouse, which has been used as a model of hearing and vestibular dysfunction, shows remarkable repetitive circling behavior. This study investigated whether the behavior is caused by the asymmetry of striatal function by observing the behavior of the bv mice following microinjection of dopamine D1 agonist, A68930 into the striatum ipsilaterally and contralaterally to the preferred direction of rotation separately. High dose of the drug induced opposite effects on ipsilateral rotations by the side of injections with statistical significance (p = .0026). These results suggested that the stereotypic circling behavior involves striatum and is based on striatal asymmetry.

Keywords: A68930; asymmetry; dopamine D1 agonist; microinjection; stereotypy; vestibular dysfunction

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00207450600936874

Affiliations: 1: Department of Developmental Disorders National Institute of Mental Health National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan and Division of Reproductive Developmental and Aging Science, The University of Tokyo Graduate School of Me 2: Department of Developmental Disorders National Institute of Mental Health National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan and Division of Reproductive Developmental and Aging Science, The University of Tokyo Graduate School of Me

Publication date: 2007-07-01

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