IS PROTEIN KINASE C (PKC) INVOLVED IN NOCICEPTION?

Authors: NIE, HONG¹; WANG, HANG¹; ZHANG, RUI-XIN¹; GAO, WANG-CAI¹; QIAO, JIAN-TIAN¹; DAFNY, NACHUM²

Source: International Journal of Neuroscience, Volume 116, Number 9, September 2006 , pp. 1115-1124(10)

Buy & download fulltext article:

Price: $42.29 plus tax (Refund Policy)

Abstract:

The study was designed to determine whether the protein kinase C (PKC) is involved in nociceptive c-Fos expression and the concomitant signaling processes of endogenous opioid-like substances (OLS) that modulate c-Fos expression in the spinal dorsal horn following formalin injection into the unilateral hindpaw in rats by using immunocytochemical techniques. In the first part of experiments in which rats were pretreated with intrathecal (i.t.) chelerythrine (Chel), an inhibitor of PKC, the nociceptive c-Fos-like immunoreactive (Fos-LI) neurons in the lumbar dorsal horn ipsilateral to the formalin injection were significantly suppressed with a reduction rate of 60.3% ( p

Keywords: chelerythrine; 11 naloxone; formalin test; nociceptive c-Fos expression; protein kinase C; rat; spinal dorsal horn

Document Type: Research article

DOI: http://dx.doi.org/10.1080/00207450600575466

Affiliations: 1: Department of Neurobiology, Shanxi Medical University, Taiyuan, Shanxi, P. R. China 2: Department of Neurobiology and Anatomy, The University of Texas Medical School at Houston, Houston, Texas, USA

Publication date: 2006-09-01

More about this publication?