Hydrazyl-nitrones, novel hybrid molecules in free radical research

Author: Ionita, Petre

Source: Free Radical Research, Volume 40, Number 1, January 2006 , pp. 59-65(7)

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Abstract:

This work describes the synthesis and characterisation of some novel hybrid molecules which contains in the same molecule a free radical moiety of hydrazyl type and a spin-trap moiety of nitrone type. The new compounds synthesized have multiple and easy to follow spectroscopic properties, making them useful as sensors or probes in radical chemistry. The new class of hydrazyl-nitrone molecules can act, in a single step process, as both generator and spin-trap of short-lived radicals. The hybrid molecules can be also involved in acid–base or redox processes, and the chemical processes can be easily monitored by visible or electron paramagnetic resonance spectroscopy. The excellent generator and trap properties recommend them as valuable sensors and probes in radical chemistry.

Keywords: Nitrone; spin-trap; radical; hydrazyl; EPR

Document Type: Research article

DOI: http://dx.doi.org/10.1080/10715760500385699

Affiliations: 1: Institute of Physical Chemistry, Spl. Independentei 202, Bucharest, Romania

Publication date: 2006-01-01

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