Lycopene, tomatoes, and coronary heart disease

Authors: Das, Samarjit; Otani, Hajime; Maulik, Nilanjana; Das, Dipak K.

Source: Free Radical Research, Volume 39, Number 4, April, 2005 , pp. 449-455(7)

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Abstract:

Tomato and its major antioxidant component lycopene have recently been focused as important antioxidant nutrients because of their ability to reduce reactive oxygen species and to provide health benefits. Most of the studies were undertaken to determine the usefulness of lycopene against cancer and cardiovascular diseases. Epidemiological studies, however, yielded conflicting results. This study was undertaken to compare cardioprotective abilities of tomato juice and lycopene. Rats were gavaged either tomato juice or lycopene for 3 weeks. At the end of 3 weeks, isolated hearts were subjected to 30?min ischemia followed by 2?h of reperfusion. Both tomato juice and lycopene reduced the extent of lipid peroxidation; but only tomato juice, but not lycopene, improved post-ischemic ventricular function, and reduced myocardial infarct size and cardiomyocyte apoptosis. The results indicated for the first time that tomato juice, but not lycopene, possesses cardioprotective ability.

Keywords: Lycopene; tomato juice; antioxidant; reactive oxygen species; ischemia/reperfusion; apoptosis

Document Type: Research article

DOI: http://dx.doi.org/10.1080/10715760500053685

Affiliations: 1: Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT, USA

Publication date: 2005-04-01

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