Reactions of Â·NO, Â·NO2 and peroxynitrite in membranes: Physiological implications
Authors: Goss, Steven P.A.; Singh, Ravinder J.; Hogg, Neil; Kalyanaraman, B.
Source: Free Radical Research, Volume 31, Number 6, 1999 , pp. 597-606(10)
Publisher: Informa Healthcare
Nitric oxide (Â·NO) and nitrogen dioxide (Â·NO2) are hydrophobic gases. Therefore, lipid membranes and hydrophobic regions of proteins are potential sinks for these species. In these hydrophobic environments, reactive nitrogen species will exhibit different chemistry than in aqueous environments due to higher local concentrations and the lack of hydrolysis reactions. The peroxynitrite anion (ONOO-) and peroxynitrous acid (ONOOH) can freely pass through lipid membranes, making peroxynitrite-mediated reactions in a hydrophobic environment also of extreme relevance. The reactions observed by these reactive nitrogen species in a hydrophobic milieu include oxidation, nitration and even potent chain-breaking antioxidant reactions. The physiological and toxicological relevance of these reactions is discussed.
Document Type: Research Article
Affiliations: Biophysics Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI, 53226-0509, USA
Publication date: 1999