4-phenyldiazenyl 2-(phenylimino methyl) phenols; synthesis and in-vitro biological evaluation as potential antibacterial agents

Authors: Halve, Anand¹; Dubey, Pushp Kant¹; Kankoriya, Amit¹; Tiwari, Kiran¹

Source: Journal of Enzyme Inhibition and Medicinal Chemistry, Volume 24, Number 1, February 2009 , pp. 176-180(5)

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By this author: Halve, Anand ; Dubey, Pushp Kant ; Kankoriya, Amit ; Tiwari, Kiran

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Abstract:

A new series of 4-phenyldiazenyl 2-(phenylimino methyl) phenols were synthesized by the condensation of 5-[(2-chloro phenyl) diazenyl] 2-hydroxybenzaldehyde with different substituted aromatic amines and sulphonamides. All the synthesized compounds were screened in-vitro for their antibacterial activity against different human pathogens viz: B. anthracis, E.coli, S. aureus, S. typhimurium, and P. aeruginosa using disk diffusion assay. All the compounds exhibited considerable inhibition against the bacteria tested.

Keywords: Antibacterial screening; imines; multidrug resistant; disc diffusion; 2-phenyldiazenyl 2-(phenylimino methyl) phenols

Document Type: Research article

DOI: 10.1080/14756360801969325

Affiliations: 1: School of Studies in Chemistry, Jiwaji University, Gwalior, India