Authors: Filho, Roberpaulo Barboza¹; Domingues, Lucilia²; Naves, Luciana³; Ferraz, Elenice²; Alves, Adriana³; Casulari, Luiz Augusto³

Source: Gynecological Endocrinology, Volume 23, Number 5, November 2007 , pp. 267-272(6)

Publisher: Informa Healthcare

Abstract:

The aims of the present study were to identify the cause of hyperprolactinemia in polycystic ovary syndrome ((PCOS)) and to compare prolactin ((PRL)) levels between PCOS women without hyperprolactinemia and women with insulin resistance and without PCOS. A group of 82 women ((age: 27.1 ±± 7.6 years)) with PCOS was included in the study. Their PRL levels were measured and compared with those of women with insulin resistance without PCOS ((controls; n == 42; age: 29.2 ±± 8.2 years)). Among the 82 PCOS women, 13 ((16%%)) presented high PRL levels ((103.9 ±± 136.0 μμg//l)). The causes of hyperprolactinemia were: pituitary tumor ((responding to cabergoline)) in nine cases ((69%%; PRL range: 28.6 -- 538 μμg//l)); oral hormonal contraceptive treatment in two cases ((15%%; PRL: 46 and 55 μμg//l, respectively)); and use of buspirone and tianeptine in one case ((8%%; PRL: 37.1 μμg//l)); one case ((8%%; PRL: 34.4 μμg//l)) had macroprolactinemia. In drug-induced hyperprolactinemic patients PRL levels normalized after treatment interruption. The average PRL level in the 69 remaining patients was 12.1 ±± 5.5 μμg//l, a value not statistically different from that of the control group ((11.8 ±± 4.9 μμg//l)). This result leads us to conclude that PCOS patients with increased PRL levels must be investigated for other causes of hyperprolactinemia, because hyperprolactinemia is not a clinical manifestation of PCOS.

Keywords: Hyperprolactinemia; polycystic ovary syndrome; insulin resistance; ovary; macroprolactinemia

Document Type: Research article

DOI: http://dx.doi.org/10.1080/09513590701297708

Affiliations: 1: 1Endocrinology and Neurology Clinics -- CLINEN, Brasíília, Brazil 2: 2Department of Obstetrics and Gynecology, University of Brasíília, Brasíília, Brazil 3: 3Endocrinology Service, University of Brasíília, Brasíília, Brazil

Publication date: 2007-11-01

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