Author: Antoniu, Sabina A

Source: Expert Opinion on Therapeutic Targets, Volume 13, Number 3, March 2009 , pp. 381-383(3)

Publisher: Informa Healthcare

Abstract:

Background: In pulmonary arterial hypertension (PAH) vascular remodelling is a complex process which involves platelet-derived growth factor (PDGF), therefore its therapeutic targeting could be useful. Objective: To evaluate PDGF as a therapeutic target in idiopathic PAH (IPAH). Methods/results: Analysis of an study evaluating the pathogenic role of PDGF in IPAH and the effects of its blockade with imatinib. In IPAH the PDGF pathway was found to be overexpressed and imatinib showed antiproliferative effects on pulmonary artery smooth muscle cells. Conclusions: These results encourage clinical evaluation of imatinib as a potential antiremodelling therapy in IPAH.

Keywords: idiopathic pulmonary arterial hypertension; imatinib; PDGF; remodelling

Document Type: Research article

DOI: http://dx.doi.org/10.1517/14728220902740817

Publication date: 2009-03-01

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