British Pharmacology Society 2nd Focused Meeting on Cell Signalling: GPCRs have sunny days in springtime Leicester

Author: Insel, Paul A

Source: Expert Opinion on Therapeutic Targets, Volume 11, Number 9, September 2007 , pp. 1251-1253(3)

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Abstract:

The British Pharmacology Society recently held its 2^nd Focused meeting on Cell Signalling in April 2007 at which a number of leading investigators from throughout the world presented findings that emphasized cellular and molecular aspects of G-protein-coupled receptor (GPCR) biology. Although the presentations highlighted both in vitro and in vivo studies, there was renewed and increased attention paid to systems with physiological (or near-physiological) levels of receptor expression. Mechanisms involved in regulating receptor expression, receptor recognition and activation by different classes of drugs, and in the interaction of G-protein-coupled receptor with other molecular entities, including heterotrimeric G proteins, were major themes of the presentations. Several speakers emphasized the challenges of drug discovery in relation to G-protein-coupled receptor, as well as their continuing importance in pharmacology and therapeutics.

Keywords: allosteric regulation; β-arrestin; chemokine receptor; glutamate receptor; G-protein-coupled receptor; receptor desensitization

Document Type: Research article

DOI: http://dx.doi.org/10.1517/14728222.11.9.1251

Publication date: 2007-09-01

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