Authors: Berthold, Dominik R¹; Moore, Malcolm J²

Source: Expert Opinion on Therapeutic Targets, Volume 10, Number 5, October 2006 , pp. 777-780(4)

Publisher: Informa Healthcare

Abstract:

Despite recent advances in the understanding of the cellular and molecular biology of prostate cancer, new options for the treatment of prostate cancer remain elusive. Targeted therapies have shown promising activities in many solid tumours and the growing number of targets and targeted agents is creating numerous opportunities for clinical research in advanced prostate cancer. At ASCO 2006 in Atlanta, a clinical science symposium on novel targets in prostate cancer was presented. It consisted of three abstracts, each of which was followed by a discussant who reviewed the work and placed it in the overall context of current approaches to treating prostate cancer. The three abstracts were a discussion of a new method for quantification of the androgen receptor; the impact of high-dose vitamin D plus chemotherapy on hormone refractory disease and on the risk of thromboembolic disease; and the paradoxical effects seen with the raf-kinase and vascular endothelial growth factor inhibitor sorafenib, which produced improvement in bone scans in the absence of any prostate-specific antigen responses.

Keywords: androgen receptor; end point determination; prostatic neoplasm; sorafinib; targeted therapy; vitamin D

Document Type: Research article

DOI: http://dx.doi.org/10.1517/14728222.10.5.777

Affiliations: 1: 1Clinical Research Fellow, Princess Margaret Hospital and University of Toronto, Department of Medical Oncology and Hematology, 610 University Avenue Toronto, Ontario M5G 2M9, Canada., Email: dominik.berthold@uhn.on.ca 2: 2Professor of Medicine and Pharmacology, Director, Bras Drug Development Program, Princess Margaret Hospital and University of Toronto, Department of Medical Oncology and Hematology, 610 University Avenue Toronto, Ontario M5G 2M9, Canada

Publication date: 2006-10-01

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