Pfizer's dual-acting 2 agonists/muscarinic M3 antagonists
Author: Norman, Peter
Source: Expert Opinion on Therapeutic Patents, Volume 18, Number 9, September 2008 , pp. 1091-1096(6)
Publisher: Informa Healthcare
Abstract:Bifunctional aromatic compounds that contain both 2 agonist and muscarinic antagonist pharmacophores linked by a flexible lipophilic spacer are claimed. The compounds display nanomolar potency with respect to both activities and appear designed to provide a long duration of action. The compounds are claimed to be useful in the treatment of both asthma and chronic obstructive pulmonary disease.
Document Type: Research Article
Publication date: September 2008