FKBP immunophilin patents for neurological disorders

Authors: Babine, Robert E; Villafranca, J Ernest; Gold, Bruce G

Source: Expert Opinion on Therapeutic Patents, Volume 15, Number 5, 1 May 2005 , pp. 555-573(19)

Publisher: Informa Healthcare

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Abstract:

Immunophilins are a family of binding proteins that are highly conserved in nature and mediate the actions of immunosuppressant drugs. The FK-506-binding protein (FKBP) subclass of immunophilin bind FK-506 and rapamycin and are of particular interest due to their potent neurotrophic activity. Here, the patent literature covering the structures of novel non-immuno-suppressant derivatives of FK-506 and rapamycin, and their claims pertaining to their potential use for the treatment of neurological disorders, are reviewed.

Keywords: FK-506; FKBP; FKBP-12; FKBP-52; immunophilin; neurodegenerative disease; tacrolimus; rapamycin

Document Type: Review article

DOI: 10.1517/13543776.15.5.555

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